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Extra resources for Annual Review of Immunology Volume 26 2008

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Heterogeneity, polypeptide composition and antigenic reactivity of C3NeF. J. Immunol. 120:1389–94 131. Austen KF. 2004. Acceptance of the Kober Medal: It only gets better. J. Clin. Invest. 114:1177 28 Austen ANRV338-IY26-02 ARI 16 February 2008 11:8 Annu. Rev. Immunol. 26:29-55. org by Shanghai Information Center for Life Sciences on 04/28/08. For personal use only. Protein Tyrosine Phosphatases in Autoimmunity Torkel Vang, Ana V. Miletic, Yutaka Arimura, Lutz Tautz, Robert C. com Annu. Rev. Immunol.

Not bound to Csk), which may bind other proteins. Such a mechanism, combined with altered ligand properties for the P1 region of LYP∗ W620, may contribute to make LYP∗ W620 a stronger inhibitor of TCR signaling compared with LYP∗ R620. We currently have some experimental evidence in support for this model (T. Vang & T. Mustelin, unpublished data). Another explanation for the augmented inhibitory effect of LYP∗ W620 on TCR signaling is altered subcellular localization, which may be tightly connected with a new set of interacting partners for LYP∗ W620 compared with LYP∗ R620.

However, the authors found no evidence for activation of Lck in CD45E613R knockin T cells, and these cells exhib- ited the same proliferative responses in vitro compared with wild-type T cells, indicating that the wedge model cannot explain important features of CD45 regulation in T cell biology (98). Furthermore, the crystal structure of CD45 is incompatible with the wedge model for several reasons (99). First, even when highly concentrated, the CD45 cytoplasmic region does not dimerize. Second, the intramolecular D1-D2 interaction appeared very tight and may not allow the deformation needed for an intermolecular D1-D1 interaction.

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