By Adrian Bot, Mihail Obrocea, Francesco M. Marincola
''Recent advances in immunology and biology have opened new horizons in melanoma treatment, integrated within the increasing array of melanoma cures, that are immunotherapies, or melanoma vaccines, for either reliable and blood borne cancers. melanoma Vaccines: demanding situations and possibilities in Translation is the 1st textual content within the box to deliver immunotherapy remedies from the laboratory trial to the bedside for the working towards oncologist. melanoma Vaccines: demanding situations and possibilities in Translation: significantly analyzes the main promising sessions of investigational immunotherapies, integrating their medical motive and scientific capability, discusses 'theranostics' as relating immunotherapy, i.e., utilizing molecular diagnostics to spot sufferers that may probably reap the benefits of a treatment, provides the recent paradigm of biomarker guided R & D and scientific improvement in immunotherapy of melanoma and experiences bottlenecks in translational means of immunotherapies and gives suggestions to solve them''--Provided by way of publisher. Read more...
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Extra resources for Cancer vaccines : from research to clinical practice
65. Murphy KM, Reiner SL. The lineage decisions of helper T cells. Nat Rev Immunol 2002; 2: 933–44. 66. Schroder K, Hertzog PJ, Ravasi T, Hume DA. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 2004; 75: 163–89. 67. Berner V, Liu H, Zhou Q, et al. IFN-gamma mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy. Nat Med 2007; 13: 354–60. 68. Kalland T, Belfrage H, Bhiladvala P, Hedlund G. Analysis of the murine lymphokine-activated killer (LAK) cell phenomenon: dissection of effectors and progenitors into NK- and T-like cells.
A Clark et al. 03). Notably, the time to objective disease progression was similar in both groups. Thus, overall survival was improved without any measurable anti-tumor effect. Antibody response against the immunizing antigen PA2024 was observed in 66% of patients in the sipuleucel-T group and 3% in the placebo group. It is interesting to note that while both T-cell and antibody responses to sipuleucel-T were observed, only antibody responses were associated with an extension of survival. Majority of adverse events were mild to moderate and included chills, fever, fatigue, nausea, and headache.
The diminished expression of human leukocyte antigen (HLA) class I antigens has been reported in several prostate cancer lines, as well as in primary and metastatic prostate tumors and is associated with poor prognosis in clear cell metastatic renal cell carcinoma (mRCC) (4,7–9). Furthermore, in spite of normal HLA expression, defective antigen processing by DCs can occur due to diminished expression of transporter-associated antigen processing (4,10). 1 Dendritic cell (DC) based immunotherapeutic strategies for prostate cancer.