By Sridhar Hannenhalli, Earl Hubbell, Robert Lipshutz, Pavel A. Pevzner (auth.), Dr. Jörg Hoheisel, A. Brazma, K. Büssow, C. R. Cantor, F. C. Christians, G. Chui, R. Diaz, R. Drmanac, S. Drmanac, H. Eickhoff, K. Fellenberg, S. Hannenhalli, J. Hoheisel, A. Ho
DNA-chip research has come a ways because the first convention in Moscow in 1991. these days, DNA-microarrays appear to be a standard commodity in organic sciences. The complexity hidden in the back of the plain ease of such reports, in spite of the fact that, is highlighted via the truth that it took approximately ten years sooner than the method rather trigger. additionally, on nearer scrutiny, one realises that a few difficulties nonetheless stay. however, microarrays produce information on a scale past mind's eye many years in the past. The authors of the ebook took half in bringing this approximately. they're famous specialists within the box, many - like Edwin Southern, Hans Lehrach, Radoje Drmanac, Pavel Pevzner and Charles Cantor - were actively pursuing array expertise for greater than a decade. They reveal the continual improvement in either know-how and alertness parts and elucidate on serious issues that must be thought of while appearing microarray analyses.
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Extra resources for Chip Technology
Southern Oligonucleotide Scanning Arrays 47 lapping footprints of the diamond-shaped mask are small diamonds but the cells created by a circular mask differ in shape: along the centre line they are lenticular but off this line they form a four-cornered “spearhead” that diminishes in size towards the edge. Each of these smaller cells contains a single oligonucleotide sequence that differs from oligonucleotides in the neighbouring cells by one or two nucleotides, depending on its position (see Fig.
55 A Study of the Secondary Structure of Nucleic Acids with Modified Bases . . . . . . . . . . . . . . 55 5 Concluding Remarks . . . . . . . . . . . . . 56 6 References . . . . . . . . . . . . . . . . 56 1 Introduction Scanning arrays are made by combinatorial in situ synthesis of a large number of oligonucleotides on a solid support in a spatially addressable fashion. They comprise sets of oligonucleotides of various lengths in which a series of oligonucleotides, complementary to the target RNA or DNA, is made by sequential coupling of nucleotides to a solid substrate (such as glass or polypropylene) that has been modified to allow oligonucleotide synthesis.
Beecher JE, McGall GH, Goldberg MJ (1997) Preprints Am Chem Soc Div Polym Mater Sci Eng 76:597 20. Beecher JE, McGall GH, Goldberg MJ (1997) Preprints Am Chem Soc Div Polym Mater Sci Eng 77:394 21. Singh-Gasson S, Green RD, Yue Y, Nelson C, Blattner F, Sussman MR, Cerrina F (1999) Nat Biotechnol 17:974 22. Cho RJ, Campbell MJ, Winzeler EA, Steinmetz L, Conway A, Wodicka L, Wolfsberg TG, Gabrielian AE, Landsman D, Lockhart DJ, Davis RW (1998) Mol Cell 2:65 23. Cho RJ, Huang M, Dong H, Steinmetz L, Sapinoso L, Hampton G, Elledge SJ, Davis RW, Lockhart DJ, Campbell MJ (2001) Nat Genet 27:48 24.