Download Chip Technology by Sridhar Hannenhalli, Earl Hubbell, Robert Lipshutz, Pavel A. PDF

By Sridhar Hannenhalli, Earl Hubbell, Robert Lipshutz, Pavel A. Pevzner (auth.), Dr. Jörg Hoheisel, A. Brazma, K. Büssow, C. R. Cantor, F. C. Christians, G. Chui, R. Diaz, R. Drmanac, S. Drmanac, H. Eickhoff, K. Fellenberg, S. Hannenhalli, J. Hoheisel, A. Ho

DNA-chip research has come a ways because the first convention in Moscow in 1991. these days, DNA-microarrays appear to be a standard commodity in organic sciences. The complexity hidden in the back of the plain ease of such reports, in spite of the fact that, is highlighted via the truth that it took approximately ten years sooner than the method rather trigger. additionally, on nearer scrutiny, one realises that a few difficulties nonetheless stay. however, microarrays produce information on a scale past mind's eye many years in the past. The authors of the ebook took half in bringing this approximately. they're famous specialists within the box, many - like Edwin Southern, Hans Lehrach, Radoje Drmanac, Pavel Pevzner and Charles Cantor - were actively pursuing array expertise for greater than a decade. They reveal the continual improvement in either know-how and alertness parts and elucidate on serious issues that must be thought of while appearing microarray analyses.

Show description

Read Online or Download Chip Technology PDF

Best technology books

Hard Drive: Bill Gates and the Making of the Microsoft Empire

The real tale in the back of the increase of a tyrannical genius, how he remodeled an undefined, and why everyone seems to be out to get him.

In this attention-grabbing exposé, investigative newshounds hint the highly winning occupation of Microsoft founder invoice Gates. half entrepreneur, half enfant bad, Gates has turn into the main robust — and feared — participant within the desktop undefined, and arguably the richest guy in the USA. In harddisk, investigative journalists Wallace and Erickson keep on with Gates from his days as an unkempt thirteen-year-old machine hacker to his present-day prestige as a ruthless billionaire CEO. greater than easily a "revenge of the nerds" tale although, this can be a balanced research of a company triumph, and a stunningly pushed character. The authors have spoken to everybody who is familiar with something approximately invoice Gates and Microsoft — from youth pals to staff and enterprise opponents who demonstrate the heights, and bounds, of his wizardry. From Gates's singular accomplishments to his both remarkable brattiness, conceitedness, and hostility (the surroundings is so extreme at Microsoft that stressed-out programmers were identified to ease the strain in their eighty-hour workweeks by means of exploding do-it-yourself bombs), it is a uniquely revealing glimpse of the individual that has emerged because the undisputed king of a notoriously brutal undefined.

Science, Technology and Society: A Sociological Approach

Technological know-how, expertise and Society: A Sociological method is a complete advisor to the emergent box of technological know-how, know-how, and society (STS) experiences and its implications for contemporary tradition and society.

The Fundamentals of Density Functional Theory

Density practical equipment shape the foundation of a different and extremely lively quarter of current days computational atomic, molecular, reliable country or even nuclear physics. various computational physicists use those meth­ ods basically as a recipe, no longer reflecting an excessive amount of upon their logical foundation. One additionally observes, regardless of in their tremendeous luck, a definite reservation of their attractiveness at the a part of the extra theoretically orientated researchers within the above pointed out fields.

Extra resources for Chip Technology

Example text

Southern Oligonucleotide Scanning Arrays 47 lapping footprints of the diamond-shaped mask are small diamonds but the cells created by a circular mask differ in shape: along the centre line they are lenticular but off this line they form a four-cornered “spearhead” that diminishes in size towards the edge. Each of these smaller cells contains a single oligonucleotide sequence that differs from oligonucleotides in the neighbouring cells by one or two nucleotides, depending on its position (see Fig.

55 A Study of the Secondary Structure of Nucleic Acids with Modified Bases . . . . . . . . . . . . . . 55 5 Concluding Remarks . . . . . . . . . . . . . 56 6 References . . . . . . . . . . . . . . . . 56 1 Introduction Scanning arrays are made by combinatorial in situ synthesis of a large number of oligonucleotides on a solid support in a spatially addressable fashion. They comprise sets of oligonucleotides of various lengths in which a series of oligonucleotides, complementary to the target RNA or DNA, is made by sequential coupling of nucleotides to a solid substrate (such as glass or polypropylene) that has been modified to allow oligonucleotide synthesis.

Beecher JE, McGall GH, Goldberg MJ (1997) Preprints Am Chem Soc Div Polym Mater Sci Eng 76:597 20. Beecher JE, McGall GH, Goldberg MJ (1997) Preprints Am Chem Soc Div Polym Mater Sci Eng 77:394 21. Singh-Gasson S, Green RD, Yue Y, Nelson C, Blattner F, Sussman MR, Cerrina F (1999) Nat Biotechnol 17:974 22. Cho RJ, Campbell MJ, Winzeler EA, Steinmetz L, Conway A, Wodicka L, Wolfsberg TG, Gabrielian AE, Landsman D, Lockhart DJ, Davis RW (1998) Mol Cell 2:65 23. Cho RJ, Huang M, Dong H, Steinmetz L, Sapinoso L, Hampton G, Elledge SJ, Davis RW, Lockhart DJ, Campbell MJ (2001) Nat Genet 27:48 24.

Download PDF sample

Rated 4.43 of 5 – based on 29 votes