By Reginald M. Gorczynski
It is a concise textual content in immunology for clinical scholars. It covers mobile, humoral and medical immunology. every one bankruptcy starts with a definition of goals by way of essentially illustrated descriptions of immunologic mechanisms. The medical implications of the knowledge in each one bankruptcy are addressed, and the chapters finish with a number of selection questions. The chapters dedicated to medical immunology finish with 3 or 4 circumstances and questions and solutions designed to "walk" scholars in the course of the situations so one can make a analysis.
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Extra resources for Clinical Immunology - An Introductory Text
L-Arginine + Oxygen iNOS ➔ L-Citrulline + Nitric oxide (NO) High levels of NO are not only toxic to microbes but may even be toxic to the phagocytes producing it, and to surrounding cells, because NO is both lipid and water-soluble. The short half-life of NO (seconds) confers some protection. However, host tissues may be damaged in a nonspecific manner. Regulation of nitric oxide synthase Induction of nitric oxide synthase (NOS) occurs in response to inflammatory products, microbial products, and/or cytokines.
One assay, the nitroblue tetrazolium (NBT) test, is used to demonstrate this defect in neutrophils. A droplet of the patient’s blood is placed onto a slide along with a neutrophil activator and NBT. NBT is a yellow dye that becomes insoluble and turns purple in the presence of NADPH oxidase activity. This genetic disorder emphasizes the role of ROIs in host defense to microbes. NATURAL KILLER CELLS Phagocytosis and activated complement are effective mechanisms for eliminating bacterial infections.
Clinical Immunology, by Reginald Gorczynski and Jacqueline Stanley. © 1999 Landes Bioscience 32 Clinical Immunology INNATE IMMUNE RESPONSES TO PATHOGENS 2 GENERAL FEATURES The innate immune system is made up of cells and molecules that function early in the protective immune response to pathogens. Cells of the innate immune system distinguish pathogens from self using primitive receptors that have a broad specificity. The innate immune system is mobilized once natural physical and chemical barriers, that normally prevent microbes from entering our bodies, have been penetrated.