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By Robin E. Callard

Over the last 5 years the key value of cytokines within the rules of the immune approach has develop into confirmed. This publication is the 1st to study the function of those elements within the keep an eye on of progress of differentiation of B lymphocytes and hence represents an up to date and well timed evaluation of the B-cell response.For the immunologist, there are unique money owed of the physio-chemical homes of the relevant Read more...

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R. E. Callard, A. J. H. Gearing and R. J. 3 4 17 4 A r a n g e of M e s t i m a t e s h a v e b e e n r e p o r t e d d u e t o a g g r e g a t i o n . H u m a n TNF-α r is c o m m o n l y f o u n d as a h o m o t r i m e r (3 x 17 K). Glycosylation m a y give rise t o s o m e M h e t e r o g e n e i t y e x c e p t for h u m a n TNF-α w h i c h h a s n o N-linked glycosyl­ r abt i o n s i t e s . c F o r m s a d i s u l p h i d e b r i d g e w h i c h is p r o b a b l y r e q u i r e d for biological activity.

Sims, J. E . , A c r e s , B . , G r u b i n , C. E . , M c M a h a n , C. , Wignall, J. M . , M a r c h , C. J. and D o w e r , S. K. (1989) Proc. Natl. Acad. Sci. USA 86, 8946-8950. Smith, C. Α . , Davis, T . , A n d e r s o n , D . , Solam, L . , B e c k m a n n , M . P . , Jerzy, R . , D o w e r , S. , C o s m a n , D . and G o o d w i n , R. G. (1990). Science24$, 1019-1023. Smith, K. A . (1984) Ann. Rev. Immunol. 2, 319-333. Smith, K. A . (1988) Science 240, 1169-1176. , Clark, E . A . and Seed, B .

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