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Additional info for Drug Addiction - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
In the future, we plan to combine this method with other methods, including EEG, so that we might begin to develop a detailed understanding of the temporal and spatial changes in brain activity during the euphoric experience. Additionally, we plan to investigate how different drugs of abuse, and some medications that might interfere with the effects of drugs of abuse, affect the human reward system. Eventually, we believe that a better understanding of the brain structures that allow us to get high, and become addicted, will lead to improved awareness and treatment for substance abuse.
Therefore, we postulate that physiologic excitation of raphe neurons is likely to produce a different regional pattern of 5-HT release than does drug-induced release, a difference that may underlie the addictive effects of drugs. ; Associate Professor; Mol Pharm, Physiology/Biotech; Brown University Providence, Ri 02912 Timing: Fiscal Year 2002; Project Start 01-APR-2002; Project End 31-MAR-2004 Summary: (provided by applicant): Recent studies provide strong evidence that glutamate receptor signaling, via both AMPA/kainate and NMDA receptors, play a mechanistic role in drug seeking responses and that addiction is a form of glutamatedependent phisticity.
Sustained exposure to opiate drugs produces adaptive changes in the nervous system that result in tolerance, dependence, and in some cases addiction. Our hypothesis is that opiate-induced synaptic plasticity forms the cellular basis of drug addiction. Ultimately, a better understanding of the consequences of prolonged opioid exposure at the cellular and molecular levels is likely to help define the changes in brain physiology responsible for opioid addiction. Generate_Screen • Project Title: CONDITIONAL MUTAGENESIS IN ADDICTION CIRCUITRY Principal Investigator & Institution: Akbarian, Schahram; Assistant Professor; Massachusetts General Hospital 55 Fruit St Boston, Ma 02114 Timing: Fiscal Year 2001; Project Start 05-SEP-2000; Project End 31-MAR-2002 Summary: As a trained psychiatrist and neuroscientist, the candidate has an ongoing commitment to increase knowledge about the molecular biology of complex behavior and to improve the treatment options for substance abuse disorders and related major psychiatric illness.