Download Natural Products for Neurodegenerative Diseases by Y.H. Wong, J.T.Y. Wong PDF

By Y.H. Wong, J.T.Y. Wong

Average items have lengthy been used for the relaxation of neurological signs, but their mechanisms of motion stay elusive. contemporary investigations have began to unveil the advanced molecular occasions linked to the healing results of ordinary items in neurodegenerative ailments. during this e-book, best specialists percentage their views and most recent learn findings at the roles of traditional items in neuroprotection and neuronal regeneration. Multifunctional houses of elements of botanicals and their derivatives are mentioned to demonstrate the chances in the direction of the advance of powerful multitarget therapeutics. Researchers within the fields of neuroscience, molecular biology, replacement drugs and pharmacology will locate that this factor presents an invaluable evaluate of some of the mechanisms underlying the healing results of usual items in neurodegenerative ailments.

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63 Bastianetto S, Zheng WH, Quirion R: The Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxideinduced toxicity: Involvement of its flavonoid constituents and protein kinase C. J Neurochem 2000;74:2268–2277. 64 Braquet P, Hosford D: Ethnopharmacology and the development of natural PAF antagonists as therapeutic agents. J Ethnopharmacol 1991;32:135–139. 65 Oyama Y, Chikahisa L, Ueha T, Kanemaru K, Noda K: Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide.

8 Zhao R, MaDaniel WF: Ginseng improves strategic learning by normal and brain-damaged rats. NeuroReport 1998;9:1618–1624. 9 Zhong YM, Nishijo H, Uwano T, Tamura R, Kawanishi K, Ono T: Red Ginseng ameliorated place navigation deficits in young rats with hippocampal lesions and aged rats. Physiol Behav 2000;69:511–525. 44 10 Mook-Jung I, Hong HS, Boo JH, Lee KH, Yun SH, Cheong MY, Joo I, Huh K, Jung MW: Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice.

However, drugs used in traditional med- icine may offer a treasury of new medicines to treat intractable diseases with the use of novel study concepts and the application of objective scientific analyses. Acknowledgments We thank Prof. M. Hattori, Dr. K. Zou, Mr. N. Matsumoto, Dr. M. R. Meselhy, Dr. N. Nakamura and Dr. J. Zhao of the Institute of Natural Medicine, Toyama Medical and Pharmaceutical University for their extensive contribution to this study. This work was supported by Kampou Science Foundation, Uehara Memorial Foundation, Grants-in-Aid for Scientific Research (B), No.

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