By Yuan-Chuan Lee (auth.), Albert M. Wu (eds.)
Based at the court cases of the 3rd overseas symposium on “Molecular Immunology of complicated Carbohydrates,” this article is the most recent in a chain devoted to glycotopes, buildings and services of advanced carbohydrates, reputation components of lectins, biomolecular interactions and different glycosciences.
Section I of the publication will pay tribute to 3 pioneers within the field—Walter T.J. Morgan, Elvin A. Kabat and particularly Winifred M. Watkins; it offers complicated thoughts about the constitution and features of Blood staff ABH/Le-related antigens, providing a entire overview on human blood crew ABH/Ii, Lea,b,x,y and siayl Lea,x glycotopes of human ovarian cyst glycoproteins. part II covers the interactions of plant, bacterial and animal lectins with carbohydrates and proteins. part III describes the buildings and services of gangliosides and microbial glycolipids. part IV covers the physiological roles of different clycocunjugates in people, animals, sponges and micro organism in addition to aging-related adjustments of glycosylation profile in people. part V discusses the position of carbohydrates as antigens and regulators of the immune reaction. part VI addresses a few points of the glycobiology of melanoma. And part VII info new methodologies in glycol-synthesis and lectin-carbohydrate binding assays and methods for therapy as the most important applications.
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Additional resources for The Molecular Immunology of Complex Carbohydrates-3
C. 8 Differential color yields of ManNAc and GlcNAc by Morgan–Elson reaction In my own experience, serendipity manifested itself while we were testing the efficacy of neoglycoproteins. 9). We had prepared BSA derivatives modified with many different sugars by many different methods . 9). One of the advantages of neoglycoproteins is that one can change the density of sugars on protein with considerably more flexibility than what nature provides. 10), thus the neoglycoprotein confirmed the known binding specificity of rabbit hepatic membrane.
7) In the chemical synthesis , they used oxaloacetic acid as a donor of pyruvic acid and carried out its condensation (aldol condensation) with GlcNAc under alkaline conditions. Chemical degradation, which yielded GlcNAc from sialic acid, also was in alkaline condition. In retrospect, it was the alkali-catalyzed epimerization of GlcNAc into ManNAc that eventually resulted in the formation of real sialic acid, which gave the same X-ray diffraction pattern as the naturally derived sialic acid.
The camel driver was tremendously impressed by their astute observations and prudence and immediately hurried off to pursue the missing camel. Perhaps the most celebrated case of serendipity, although not directly related to glycosciences, is the “discovery” of America by Christopher Columbus in 1492. Columbus firmly believed that the earth was round and thus one could reach China or India by westward voyage from Europe over what was presumed to be an open sea. By attempting to find a sea route to the rich continent of Cathay (China), India, and the fabled gold and spice islands of the East, Columbus hoped to gain riches for his family and to join the ranks of the nobility of Spain.